Dendritic h Channelopathy in Epileptogenesis
نویسندگان
چکیده
Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells.
منابع مشابه
Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy.
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Epilepsy is associated with loss of expression and function of hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channels. Previously, we showed that loss of HCN channel-mediated current (I(h)) occurred in the dendrites of CA1 hippocampal pyramidal neurons after pilocarpine-induced status epilepticus (SE), accompanied by loss of HCN1 channel protein expression. However, the precise...
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ورودعنوان ژورنال:
- Neuron
دوره 44 شماره
صفحات -
تاریخ انتشار 2004